Electric Literature of 77112-53-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 77112-53-9 name is Imidazo[1,2-a]pyrazine-2-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 5: Imidazo[l,2-alpha]pyrazine-2-carboxylic acid [2-(4-{4-[(5S)-(acetylamino-methyl)-2- oxo-oxazolidin-3-yl]-2,6-difluoro-phenyl}-piperazin-l-yl)-2-oxo-ethyl]-amide; To a solution of compound (300 mg, 0.57 mmol) obtained in step 4, in DMF (10 mL), were added imidazo[l,2-alpha]pyrazine-2-carboxylic acid (107 mg, 0.66 mmol), EDC (127 mg, 0.66 mmol), HOBt (89 mg, 0.66 mmol) and NMM (0.15 mL, 1.35 mmol) at 0 0C. The reaction mixture was stirred at r.t. and progress of the reaction was monitored by TLC. On completion, DMF was evaporated in vacuo and residue was dissolved in chloroform (100 mL). The organic layer was washed with water (50 mL), brine (50 mL), dried over anhydrous sodium sulphate and concentrated in vacuo. The residue was purified by column chromatography (silica gel, 1 :20 methanolxhloroform) to provide title compound (220 mg, 69%) as white solid.1H NMR (400 MHz, CDCl3, delta): 2.03 (s, 3H), 3.10-3.25 (m, 4H), 3.50-3.65 (m, 3H), 3.65- 3.75 (m, 2H), 3.80-3.90 (m, 2H), 4.00 (t, J = 9.0 Hz, IH), 4.34 (d, J = 4.5 Hz, 2H), 4.70- 4.85 (m, IH), 5.97 (t, J = 6.1 Hz, IH), 7.12 (d, J = 10.9 Hz, 2H), 7.94 (d, J = 4.7 Hz, IH), 8.09 (dd, J = 4.6 and 1.5 Hz, IH), 8.22 (d, J = 0.5 Hz, IH), 8.35 (t, J = 4.4 Hz, IH), 9.13 (d, J= 0.9 Hz, IH).ESIMS (m/z): 579.3 (M+23), 557.3 (M+l)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Imidazo[1,2-a]pyrazine-2-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; PANACEA BIOTEC LTD.; JAIN, Rajesh; TREHAN, Sanjay; DAS, Jagattaran; KANWAR, Sandeep; MAGADI, Sitaram, Kumar; SHARMA, Sudhir, Kumar; WO2010/58423; (2010); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem