89180-45-0, name is 5-Chloro-2-hydroxypyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 89180-45-0
A mixture of 2-hydroxy-5-chloropyrazine in POCl3 (21 equiv.) was heated at 1200C for 2 h. The reaction mixture was cooled and poured on ice and extracted with dichloromethane. The organic solvent was collected, dried over Na2SO4 and filtered. The solvent was filtered over silica gel followed by ethyl acetate. The solvents were evaporated to provide the title compound
The synthetic route of 89180-45-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK FROSST CANADA LTD.; WO2008/46226; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem