Electric Literature of 179323-60-5, These common heterocyclic compound, 179323-60-5, name is 1-(Pyrazin-2-yl)ethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 3 4′-Methyl-5-(2-oxo-benzooxazol-3-yl)-biphenyl-3-carboxylic acid-1-pyrazin-2-yl-ethyl)-amideThe 4′-methyl-5-(2-oxo-benzooxazol-3-yl)-biphenyl-3-carboxylic acid from step 2, together with 1-pyrazin-2-yl-ethylamine (0.2 mL, excess), HOAt (10 mg, catalytic amount), NMM ((0.5 mL) and ECDI (200 mg) were added to DMF (4 mL), and the resulting mixture was stirred overnight at room temperature. The reaction mixture was partitioned between water and ethyl acetate. The organic layer was concentrated under reduced pressure and the resulting residue was purified by preparative thin layer chromatography (5% MeOH in dichloromethane) to give 58 mg (36% yield overall) of 4′-methyl-5-(2-oxo-benzooxazol-3-yl)-biphenyl-3-carboxylic acid-1-pyrazin-2-yl-ethyl)-amide, MS (M+H)=451.
Statistics shows that 1-(Pyrazin-2-yl)ethanamine is playing an increasingly important role. we look forward to future research findings about 179323-60-5.
Reference:
Patent; Chen, Li; Dillon, Michael Patrick; Feng, Lichun; Yang, Minmin; US2010/324069; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem