Related Products of 5521-55-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5521-55-1 name is 5-Methylpyrazine-2-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Weigh 3.0g (7.38mmol) GK and 1.22g (8.86mmol, 1.2eq)The 5-methylpyrazine-2-carboxylic acid was dissolved in 50 mL of acetonitrile and mixed in an ice bath with stirring.Then 0.09 g (1.48 mmol, 0.1 eq) of 4-dimethylaminopyridine (DMAP) and1.84 g (9.59 mmol, 1.3 eq) of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC.HCl),After stirring in an ice bath for 1 hour, the mixture was reacted at 20C for 4 hours, and the solvent was removed by rotary evaporation.The crude product was dissolved in ethyl acetate and washed twice with 5% NaHCO3 and once with saturated brine.The organic phase is dried, filtered and concentrated.Column chromatography (V petroleum ether: V EtOAc = 2:1) gave 1.82 g of GKC as a white solid.Yield 46.91%, HPLC purity 98.96%
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Methylpyrazine-2-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; Chengdu Baiyu Pharmaceutical Co., Ltd.; Li Daxiong; Ke Hong; Fan Xiaobo; Sun Yi; (17 pag.)CN108069980; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem