Synthetic Route of 89123-58-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89123-58-0 name is 5-Bromopyrazine-2,3-diamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 2; A solution of 2 (1.05 g, 5.52 mmol) in acetic acid diethoxy methyl ester (5 mL) was heated at 130 C. for 3 h. After completion of reaction (reaction progress was monitored by TLC), the reaction mixture was cooled to 25 C. and diluted with hexane. Hexane layer was decanted and crude reaction mass was washed with hexane (3×20 mL) to afford 3 as crude a yellow solid (900 mg, 81%), which was directly used in the next step without further purification. MS m/z (ES): 198 (M+H)+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromopyrazine-2,3-diamine, and friends who are interested can also refer to it.
Reference:
Patent; de Vicente Fidalgo, Javier; Hermann, Johannes Cornelius; Lemoine, Remy; Li, Hongju; Lovey, Allen John; Sjogren, Eric Brian; Soth, Michael; US2011/59118; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem