Reference of 61655-72-9, A common heterocyclic compound, 61655-72-9, name is 6-Chloro-N,N-dimethylpyrazin-2-amine, molecular formula is C6H8ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 24 6-(N,N-dimethylamino)-2-(1-piperazinyl)pyrazine dihydrochloride Twenty millimoles (3.14 g.) of 6-(N,N-dimethylamino)-2-chloropyrazine and piperazine (3 g.) are fused under N2 at 135° for 6 hours. The mixture is digested with water and after filtering to remove insolubles, is basified with 10 N sodium hydroxide and extracted with chloroform. The combined chloroform extracts are washed with 2 N sodium hydroxide, dried (sodium sulfate, anhyd.), filtered, and concentrated to an oil under reduced pressure. The product is isolated as the dihydrochloride salt, m.p. 249°-250°, from isopropanol.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Merck & Co., Inc.; US4081542; (1978); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem