Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 23688-89-3, name is 6-Chloropyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C5H3ClN2O2
A mixture of 6-chloropyrazine-2-carboxylic acid [CAS-RN: 23688-89-3] (1.00 g,6.31 mmol, 1.0 eq), tert-butyl 4-aminopiperidine-1-carboxylate [CAS-RN: 87120-72-7] (1.39 g, 6.94 mmol, 1.1 eq), HATU (2.64 g, 6.94 mmol, 1.1 eq) and DIPEA(2.33 mL, 12.6 mmol, 2.0 eq) was dissolved in 38 mL DMF and stirred at rt overnight. The reaction mixture was partitioned between ethyl. acetate and water. The organic phase was washed with brine and filtered through a Whatman filter. The volatile components were removed in vacuo and the crude material obtained was purified via preparative MPLC (Biotage Isolera; 50 g SNAPcartridge: hexane-> hexane/ethyl acetate 2/3) to give 2.1 g (94% yield of theory) of the title compound.UPLC-MS (Method 2): R = 1.14 mm; MS (Elneg) m/z = 339 [M-H].
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 23688-89-3.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; SIEMEISTER, Gerhard; HEINRICH, Tobias; PRECHTL, Stefan; STOeCKIGT, Detlef; ROTTMANN, Antje; WO2015/113927; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem