Synthetic Route of 243472-70-0, A common heterocyclic compound, 243472-70-0, name is 5-Bromo-2,3-diphenylpyrazine, molecular formula is C16H11BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The reaction flask was charged with 5-bromo-2,3-diphenylpyrazine (100 g, 0.32 mol)4-Isopropylamino-1-butanol (127 g, 0.96 mol) andPotassium iodide (15.9 g, 0.096 mol) was added and the mixture was heated to 150 C for 16 hours.After the system was cooled to room temperature, ethyl acetate (800 mL)Washed with water (800 mL × 2), dried over anhydrous sodium sulfate, filtered,The filtrate was concentrated under reduced pressure and the residue treated with dichloromethane / heptane (1.2 L, v / v = 1: 5)Recrystallization, get4 – ((5,6-diphenylpyrazin-2-yl) – (isopropyl) amino) -1-butanol(75.5 g, yield: 65.3%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Hangzhou East China Pharmaceutical Group New Drug Institute Co., Ltd.; Zhang Qianqian; Qu Xiaoxia; (14 pag.)CN107365275; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem