Electric Literature of 6705-33-5, A common heterocyclic compound, 6705-33-5, name is Pyrazin-2-ylmethanol, molecular formula is C5H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: These compounds were synthesized according to previously reported method.4 28a was purchased from commercial sources and used as received. To a solution of 27a-27c (1.0 mmol) in Et2O (10 mL) was added 60% NaH (1.0 mmol). The reaction mixture was stirred at rt for 10 min before adding trichloroacetonitrile (1.0 mmol) at once. The resulting solution was stirred for 2-5 h and the solvent was removed under reduced pressure. The crude product was purified by silica gel column chromatography to yield the desired compounds 28a-28c.
The synthetic route of 6705-33-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Xu, Yulong; Yang, Xicheng; Chen, Yiyi; Chen, Hao; Sun, Huijiao; Li, Wei; Xie, Qiong; Yu, Linqian; Shao, Liming; Bioorganic and Medicinal Chemistry Letters; vol. 28; 12; (2018); p. 2148 – 2152;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem