Electric Literature of 762240-92-6, These common heterocyclic compound, 762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 250 ml three-necked flask,Add 100 ml of dichloromethane,(3R)-3 tert-Butoxycarbonylamino-4-(2,4,5-trifluorophenyl)-butyric acid (VI) (6.6 g, 0.02 mol) and3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride (VII) (4.6 g, 0.02 mol) ,Cool to 0 C with an ice salt bath.Add 1-hydroxybenzotriazole (HOBT) (2.7 g, 0.02 mol),1-ethyl-3-(3-dimethylaminopropyl)carbimide hydrochloride (EDC.HCl) (3.82 g, 0.02 mol),Triethylamine (6 g, 0.03 mol) was added dropwise.Reaction for 24h,The reaction solution was washed twice with 50 ml of distilled water.dry,filter,Concentration gave the crude product (9.62 g, 0.019 mol).The yield was 95%.
The synthetic route of 762240-92-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhejiang Yongtai Technology Co., Ltd.; Zhejiang Yongtai Pharmaceutical Co., Ltd.; Zhang Feng; Cheng Xuyang; Tan Xiao; (19 pag.)CN109824546; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem