Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 957230-70-5, name is 3,6-Dibromopyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., name: 3,6-Dibromopyrazin-2-amine
Specifically for weighing 2-amino-3,6-dibromopyrazine2.53g and NaNO21.38g in a 100ml round bottom flask,425 ml of HBF was slowly added dropwise thereto at 0 C, and the reaction was performed at 20 C for 2 hours.The reaction mixture was washed with water and extracted three times with dichloromethane.The organic phase was collected.The obtained organic phase was purified by silica gel column chromatography,This gave 2,5-dibromo-3-fluoropyrazine.Then, 140 mg of the obtained 2,5-dibromo-3-fluoropyrazine, 523 mg of 4- (diphenylamino) phenylboronic acid pinacol ester, and 119 mg of bis (triphenylphosphine) palladium (II) dichloride were taken.142 mg of tetrabutylammonium bromide was placed in a 50 ml reaction tube, 5 ml of K2CO3 solution (6 mol / L) and 10 ml of toluene were added under N2 protection, and the reaction was performed at 85 C. for 24 h.The reaction product was washed with water and extracted three times with dichloromethane, and the organic phase was collected.Purified by silica gel column chromatography.54 mg of 4,4 ‘-(3-fluoropyrazine-2,5-diyl) bis (N, N-diphenylaniline) was obtained as a yellow solid.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 957230-70-5.
Reference:
Patent; Xi’an Jiaotong University; Chen Kai; Wu Shuqi; Bian Xiaoli; Wang Qiutang; (12 pag.)CN110540524; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem