In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C5HCl2N3
3.49 g of potassium fluoride and 1.33 g of tetrabutylammonium bromide were suspended in a mixed solvent containing 40 ml of toluene and 20 ml of dimethyl sulfoxide. The toluene was subsequently removed by distillation at normal pressure. A further 40 ml of toluene was then added and once again removed by distillation, thereby removing moisture from the system. 14.08 g of a toluene solution of 3,6-dichloropyrazine-2-carbonitrile with a concentration of 24.7% was then added to the reaction system, and the resulting mixture was stirred at 60 C. for 2.5 hours. Subsequently, 20 ml of toluene and 30 ml of water were added, and a separation was performed. The organic layer was washed with 20 ml of water, 20 ml of water and concentrated hydrochloric acid were then added to the organic layer to adjust the pH to 1.6, and another separation was performed. The organic layer was then washed with 20 ml of a 5% saline solution. Quantitative analysis by HPLC of the obtained organic layer revealed an equivalent yield of pure 3,6-difluoropyrazine-2-carbonitrile of 2.60 g (yield: 92.3%).
The synthetic route of 356783-16-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nippon Soda Co., Ltd.; US2011/275817; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem