Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19847-12-2, name is Pyrazinecarbonitrile, A new synthetic method of this compound is introduced below., Product Details of 19847-12-2
General procedure: A mixture of nitrile (4 mmol), ethylenediamine or 1,3-diaminopropane (5 mmol), NaOAc (1.1 mmol), I2 (0.4 mmol), and CuL2 (0.4mmol) was irradiated with microwave (800 W) for 10-25 min by pulsed irradiation. At the end of the reaction (monitored by TLC, EtOAc-MeOH, 3:1), the mixture was cooled to r.t., CHCl3 was then added and the catalyst was filtered. Evaporation of the solvent gave the almost pure product. Further purification was performed as for the procedure used in the synthesis of imidazolines and tetrahydropyrimidines under reflux conditions.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; An, Shujuan; Yin, Bing; Liu, Ping; Li, Xiangnan; Li, Chen; Li, Jianli; Shi, Zhen; Synthesis; vol. 45; 18; (2013); p. 2525 – 2532;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem