Application of 119165-68-3,Some common heterocyclic compound, 119165-68-3, name is 2-(1H-Imidazol-2-yl)pyrazine, molecular formula is C7H6N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 2: 2-( l -{ [2-(Trimethylsilyl ethoxy1methyl}-l H-imidazol-2-yI)pyrazineTo a solution of 2-(lH-imidazol-2-yl)pyrazine (0.75 g, 5.1 mmol) in DMF (7 mL) was added sodium hydride (60% dispersion in oil, 0.42 g, 10.3 mmol) and the reaction stirred at 40C for 2 hours. [2-(chloromethoxy)ethyl](trimethyl)silane ( 1.71 g, 10.3 mmol) was added and the reaction was stirred at 40C for a further 3 hours The reaction mixture was partitioned between EtOAc and water and the layers separated. The aqueous layers was extracted with EtOAc (x2) and the combined organic layers were dried (MgS04), filtered and concentrated in vacuo. The residue was purified using column chromatography (gradient 20-60% EtOAc in hexane) to give the title compound (0.88 g, yellow oil). NMR (400 MHz, CDC13) delta ppm: 9.47 (d. J=1.0 Hz, 1 H), 8.36 – 8.59 (m, 2 H), 7.26 – 7.28 (m, 1 H), 7.24 (d, J=1.3 Hz, 1 H), 5.96 – 6.00 (m, 2 H), 3.53 – 3.61 (m, 2 H), 0.86 – 0.94 (m, 2 H), -0.10 – -0.05 (m, 9 H).
The synthetic route of 119165-68-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD; DIMOPOULOS, Paschalis; HALL, Adrian; KITA, Yoichi; MADIN, Andrew; SHUKER, Nicola Louise; WO2012/93148; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem