Synthetic Route of 4430-75-5, A common heterocyclic compound, 4430-75-5, name is Octahydro-2H-pyrido[1,2-a]pyrazine, molecular formula is C8H16N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step A Ethyl 3-(octahydro-2H-pyrido[1,2-a]pyrazin-2-yl)propanoate A solution of 3.5 g of octahydro-2H-pyrido[1,2-a]pyrazine and 8 ml of ethyl acrylate in 50 ml of acetonitrile is refluxed for 24 hours. The solvent is removed in vacuo to yield the expected product.
The synthetic route of 4430-75-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Goldstein, Solo; Poissonnet, Guillaume; Parmentier, Jean-Gilles; Lestage, Pierre; Lockhart, Brian; US2003/195216; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem