Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 33332-25-1, name is Methyl 5-chloropyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., Computed Properties of C6H5ClN2O2
To a solution of methyl 5-chloropyrazine-2-carboxylate (I, 30.0 g, 0.174 mol) in acetonitrile (120 mL) TMSBr (45.1 mL, 0.348 mol) was added under nitrogen atmosphere. The mixture was stirred and heated at 80 C for 5 h while volatile component (105 mL) was distilled away under reduced pressure (atmospheric pressure to 800 hPa). After the mixture was cooled to 0 C, water (150 mL) was added while keeping the internal temperature at 0 to 8 C, and the mixture was stirred at 0 C for 1 h. The precipitated solids were collected by filtration, washed with water (120 mL), and dried under reduced pressure at 50 C to provide 35.0 g of the title compound (II) (93% yield) as brown solids. The ratio of I and II was 1.1 :98.9 by its HPLC analysis.
The synthetic route of 33332-25-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; YOSHIZAWA, Kazuhiro; OMORI, Masayuki; WATANABE, Yuzo; NAGAI, Mitsuo; TAKAHASHI, Masabumi; FANG, Frank; WO2013/162065; (2013); A1;,
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