Synthetic Route of 957230-70-5,Some common heterocyclic compound, 957230-70-5, name is 3,6-Dibromopyrazin-2-amine, molecular formula is C4H3Br2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 3,6-dibromo-pyrazin-2-ylamine (15.37 g, 60.80 mmol) and N,N- dimethylformamide dimethyl acetal (10. ImL, 76.00 mmol), suspended in ethanol (15O mL), is refluxed for 2 hours. The reaction mixture is evaporated in vacuo affording the title compound (18.6 g). 1H-NMR (400MHz, CDCl3) delta(ppm) 3.20 (s, 3H), 3.21 (s, 3H), 7.93 (s, IH), 8.48 (s, IH). LCMS: Rt 3.81 min (99.1%), m/z (APCI) 307 (M+H)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,6-Dibromopyrazin-2-amine, its application will become more common.
Reference:
Patent; GALAPAGOS N.V.; WO2007/138072; (2007); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem