Adding a certain compound to certain chemical reactions, such as: 486460-20-2, name is 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 486460-20-2, Recommanded Product: 486460-20-2
A mixture of compound 10 (12.0 g, 0.064 mol) and the catalyst,Pd/C (10% w/w, 120.0 mg) in methanol (MeOH)(120 mL) was charged into an autoclave (500 mL) at ambienttemperature. The reaction mass was agitated for 24 h bymaintaining 3.5-4.5 Kg/cm2 hydrogen pressure at 40-45 C.The completion of reaction was judged by TLC. The reactionmass was concentrated under reduced pressure afterremove the Pd/C catalyst by passing through celite undernitrogen atmosphere. The residue was dissolved in IPA(24.0 mL) and then IPA.HCl (24.0 mL) was added slowly at 0-5 C. The precipitated solid was separated by filtration,after one hour agitation of the reaction mass, to obtain 3-trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo-[4,3-a]pyrazinehydrochloride (11) as a white crystalline solid (12.1 g, 82.9%).m.p.: 237-249 C (Lit. 236-246 C reported in chemical book).1H NMR (400MHz; DMSO-d6), d, ppm (J, Hz): 3.65 (2H, t,J5.6, Piperazine); 4.46 (2H, t, J5.6, Piperazine); 4.61(2H, s, Piperazine); 10.58 (2H, br, NH2). 13C NMR(100MHz; DMSO-d6) d, ppm (J, Hz): 39.09 (-CH2-CH2-),40.14 (-CH2-CH2-), 40.90 (-CH2-), 117.17 (d, J268.4, CF3),142.29 (C triazole), 148.73 (C triazole). LC-MS m/z (rel, %):193.08 (M+H)+ (100).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Mannam, Madhava Rao; Devineni, Subba Rao; Pavuluri, Chandra Mouli; Chamarthi, Naga Raju; Kottapalli, Raja Sekhara P.; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 194; 9; (2019); p. 922 – 932;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem