Related Products of 123-32-0,Some common heterocyclic compound, 123-32-0, name is 2,5-Dimethylpyrazine, molecular formula is C6H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
he 2,5-dimethyl pyrazine (1.08g, 10mmol), methanol (30ml, 742mmol) and 30% sulfuric acid (47ml, 175.4mmol) was added 500ml of four-necked flask, stirring speed, ambient temperature and pressure At the same time at the same speed inwardly slowly dropped 30% H2O2(7ml, 68.4mmol) and a saturated aqueous solution of ferrous sulfate (6.35g, 22.8mmol), the reaction temperature is controlled at 30 ~ 60 , addition was complete, the reaction was completed.The reaction solution was adjusted with sodium hydroxide to pH = 9, was centrifuged, the precipitate portion was washed once with water, the combined aqueous layer was concentrated to dryness, and extracted three times respectively, filtration, filtrate was washed with 250ml of ethyl acetate was distilled under reduced pressure to recover the solvent, the crude product was liguzinediol , column chromatography on silica gel, petroleum ether: ethyl acetate = 3 eluted, recrystallized from ethyl acetate to give white needle crystals 0.52g, yield 31%, purity 99.3%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,5-Dimethylpyrazine, its application will become more common.
Reference:
Patent; Nanjing University of Chinese Medicine; Li, Wei; Wen, Hong Mei; Wang, Tianlin; Zhou, Ying; Chen, Lei; (6 pag.)CN103242247; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem