In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 312736-50-8, name is 3,5-Dichloropyrazine-2-carboxamide belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 3,5-Dichloropyrazine-2-carboxamide
107261 To a solution of 3,5-dichloropyrazine-2-carboxamide (Example 12, Step 2, 52 g, 0.27 mol) in acetonitrile (1 L) was added POC13 (146 g, 89 mL, 0.95 mol) at room temperature. The mixture was heated to 90-100 C for 4 h. The mixture was cooled to room tempetature and poured slowlyinto a vigorously stirring solution of saturated aq. NaHCO3. Evolution of gas was observed. The mixture was extracted with EtOAc (3 x). The combined organic layers were dried over sodium sulfate then concentrated under reduced pressure to give a residue. The residue was purified by silica gel chromatography (0-30% EtOAc in hexanes) to give the title compound as a pale yellow solid. ?H NIVIR (400 MHz, CDC13): ppm 8.64 (s, 1H): ?3C NMR (101 IVIFIz, CDC13) ppm 150.8,150.43, 143.24, 128.06, 113.06.
The synthetic route of 312736-50-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FLX BIO, INC.; BECK, Hilary, Plake; BIANNIC, Berenger; BUI, Minna Hue, Thanh; HU, Dennis, X.; KETCHAM, John, Michael; POWERS, Jay, Patrick; REILLY, Maureen, Kay; ROBLES-RESENDIZ, Omar; SHUNATONA, Hunter, Paul; WALKER, James, Ross; WUSTROW, David, Juergen; YOUNAI, Ashkaan; ZIBINSKY, Mikhail; (396 pag.)WO2018/22992; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem