Related Products of 76537-18-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 76537-18-3, name is 3-Bromo-5-chloropyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows.
A 40 mL vial was charged with 3-bromo-5-chloropyrazin-2-amine (150 mg, 0.72 mmol, Ark Pharm), cesium fluoride (328 mg, 2.16 mmol), 2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole (178 mg, 0.79 mmol, Combi-blocks), bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II) (13 mg, 0.018 mmol), l-butanol (3 mL), and water (0.75 mL). The mixture was sparged with N2 for 5 min, then heated to 60 C for 1H. The reaction mixture was partitioned between water and EtOAc, and the layers were separated. The organic layer was washed with brine, dried over MgSCL, filtered, and concentrated. The residue was purified by flash chromatography (0-100% EtO Ac/hexanes) to afford the title compound as a tan solid (140 mg, 86%). LCMS calculated for CXFLC1N4S (M+H)+: m/z = 227.0, found: 227.0.
The chemical industry reduces the impact on the environment during synthesis 3-Bromo-5-chloropyrazin-2-amine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; INCYTE CORPORATION; SHVARTSBART, Artem; COMBS, Andrew, P.; FALAHATPISHEH, Nikoo; POLAM, Padmaja; SHAO, Lixin; SHEPARD, Stacey; (170 pag.)WO2019/126505; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem