Electric Literature of 88625-24-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 88625-24-5, name is 5-Chloropyrazine-2-carbaldehyde belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Intermediate 19 ethyl { l-i”5-(“5-formylpyrazin-2-vl)pyrimidin-2-yl]piperidin-4-vnacetateTo a mixture of ethyl {l-[5-(4,4,5,5-tetramethyl-l ,3,2-dioxaborolan-2-yi)pyrimidin-2- yl]piperidin-4-yl} acetate (Intermediate 18), 0.5 g, 1.33 mmol, 1.00 equiv), 5-chJoropyrazine-2- carbaldehyde (0.377 g, 2.66 mmol, 2.00 equiv), tetrakis (0.231 g, 0.2 mmol, 0.15 equiv) and Na2P¾ (2.66 mL, 2.0 M, 4.0 equiv) was added DME (13.0 mL)/EtOH (8.0 mL). The reaction mixture was degassed and purged with nitrogen with stirring for 10 min followed by MW at 120 C for 20 min. Solvent evaporated and mixture diluted with water and extracted 3x with EtOAc. The organic layers were combined, dried over MgS04 and concentrated in vacuo. The residue was purified by eluting through a silica gel column with a 0-70% EtOAc/Hexane solvent system to provide product ethyl { l-[5-(5-formylpyrazin-2-yi)pyrimidin-2-yl]piperidin-4-yl}acetate. LC- MS (ES, m/z) CisH21N503: 355; Found: 356 [M+H)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloropyrazine-2-carbaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; BALKOVEC, James, M.; KRIKORIAN, Arto, D.; GUIADEEN, Deodial; YANG, Ginger; JIAN, Tianying; WU, Zhicai; YU, Yang; NARGUND, Ravi, P.; VACHAL, Petr; DEVITA, Robert, J.; HE, Shuwen; LAI, Zhong; BLEVIS-BAL, Radhika, M.; CERNAK, Timothy, A.; SPERBECK, Donald, M.; HONG, Qingmei; WO2012/96813; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem