Reference of 98-97-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 98-97-5, name is Pyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.
Figure ID shows a table of products produced by using a catalytic redox system comprising 20 mol % organocatalyst lg and 10 mol % CuI2(NMI)4 in MeCN under dry air (4 A molecular sieves) at 50 C, a variety of amides were constructed from 1.0 equiv of a carboxylic acid, 1.2 equiv of an amine, and 1.5 equiv of triethyl phosphite. For workup and isolation, the MeCN was filtered, and the solids were washed with CH2C12. The solvents were evaporated, and the products were obtained by Si02 chromatography. The entries span 1 and 2 amines, aliphatic and aromatic amines, amino acids and amino alcohols/phenols. The method is compatible with oxidation-prone substrates such as alkenes, boron derivatives, and furans and indoles as well as with electron-deficient heterocycles and benzene derivatives, and it works well for amines with a significant range of piH), chiral amine partners, chiral acid partners, and others. No racemization of stereocenters was observed for those substrates studied. The synthesis of peptide 3a shown in was carried out on a 5 g scale and delivered the product in 91% yield after 24 h at 50 C.
The chemical industry reduces the impact on the environment during synthesis Pyrazine-2-carboxylic acid. I believe this compound will play a more active role in future production and life.
Reference:
Patent; EMORY UNIVERSITY; LIEBESKIND, Lanny Steven; GANGIREDDY, Pavan Kumar Reddy; AKONDI, Sri Rama Murthy; (97 pag.)WO2017/70157; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem