369638-68-6, name is tert-Butyl (5-methylpyrazin-2-yl)carbamate, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of tert-Butyl (5-methylpyrazin-2-yl)carbamate
Step 2: 5-Methyl-2-aminopyrazine. To a stirred solution of (5-methyl-pyrazin-2-yl)-carbamic acid tert-butyl ester (2.1 g, 10 mmol) in 30 mL CH2Cl2 at 0 C. under nitrogen was added trifluoroace (30 mL). The solution was allowed to warm to RT overnight. The solution was rotary evaporated to remove TFA and the residue was redissolved in 200 mL CH2Cl2 and stirred with 100 mL 10% Na2CO3. The organics were isolated and the aqueous solution extracted 3*100 mL with CH2Cl2. The organics were combined, dried (MgSO4), filtered and concentrated to an orange solid (1 g, 92%). 1H-NMR (400 MHz, CDCl3) delta8.46 (s, 1H), 7.70 (s, 1H), 2.49 (s, 3H).
The synthetic route of 369638-68-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Keegan, Kathleen S.; Kesicki, Edward A.; Gaudino, John Joseph; Cook, Adam Wade; Cowen, Scott Douglas; Burgess, Laurence Edward; US2003/69284; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem