Related Products of 36070-75-4, A common heterocyclic compound, 36070-75-4, name is 5-Chloropyrazine-2-carbonitrile, molecular formula is C5H2ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of A-5 (1.5 g, 10.75 mmol) and 5% Pd/C (150 mg) in TFA (15 mL, 201.94 mmol) and (2,2,2-trifluoroacetyl) 2,2,2-trifluoroacetate (8 mL, 57.55 mmol) was stirred under H2 (15 psi) at 20 C for 5 hours. The mixture was filtered through Celite, eluted with EtOAc (20 mL), and concentrated to a residue. The residue was diluted with H20 (30 mL) and sat.Na2C03 (30 mL) and extracted with EtOAc (50 mL x 2). The combined organic phase was washed with water (20 mL x 2) and brine (20 mL), dried over Na2S04, filtered and concentrated to give the crude product, which was purified by flash chromatography on silica gel (EtOAc in PE = 20% to 30% to 50%) to afford A-21 (2100 mg, 8.72 mmol) as a solid. 1H NMR (400MHz, CDCls) deltaalpha = 8.58 (d, 1H), 8.43 (s, 1H), 7.38 (br s, 1H), 4.71 (d, 2H). LCMS R, = 0.61 min using Method B, MS ESI calcd. for C7H6C1F3N30 [M+H]+ 240.0, found 239.9.
The synthetic route of 36070-75-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PRAXIS PRECISION MEDICINES, INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (141 pag.)WO2018/98491; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem