Application of 914452-71-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 914452-71-4, name is 2-Bromo-6-methylpyrazine, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 2-bromo-6-methyl-pyrazine (3.0 g, 17.31 mmol) in CCl4 (25 mL) was added NBS (4.60 g, 26.01 mmol) and AIBN (0.248 g, 1.734 mmol) at RT. The mixture was stirred at 55 C. for 48 h. H2O was added followed by extraction with EtOAc (3*100 mL). The combined organics were washed with brine, dried (Na2SO4) and concentrated in vacuo. The residue was purified over silica eluting with 5% EtOAc:Hexane to obtain i (1.40 g, 32%). 1H NMR (CDCl3, 400 MHz): delta 8.64 (s, 1H), 8.62 (s, 1H) and 4.50 (s, 2H).
The chemical industry reduces the impact on the environment during synthesis 2-Bromo-6-methylpyrazine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Biota Europe Ltd.; Lunniss, Christopher James; Palmer, James T.; Pitt, Gary Robert William; Davies, David; Axford, Lorraine Claire; US2013/252938; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem