Adding a certain compound to certain chemical reactions, such as: 4949-13-7, name is 2-Fluoropyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4949-13-7, SDS of cas: 4949-13-7
Reagent 142-Fluoro-3-(tributylstannyl)pyrazineA clear solution of 2,2,6,6-tetramethylpiperidine (4.1 ml, 24.29 mmol) in tetrahydrofuran (150 mL) was cooled to -30 C and treated with n-butyl lithium (9.0 ml, 22.50 mmol). The internal temperature (IT) rose from -37 to -26 C. The reaction mixture was stirred at room temperature (IT=15 C) for 0.5 hours and then placed in a N2(1)/MeOH bath and cooled to an internal temperature of -122 C. A solution of 2-fluoropyrazine (2.0889 g, 21.30 mmol) in tetrahydrofuran (50 ml) was added via cannula over 4 minutes (IT=103). After 5 min, the tributyltin chloride (7 ml, 25.81 mmol) was added and the mixture was maintained at -100 C for 1 hr 40 minutes. The dark brown solution was quenched with 1:4:5 35% aqueous HCl:EtOH:THF, allowed to warm to room temperature over 35 minutes, made slightly basic with sodium bicarbonate, concentrated to a residue, and then partitioned between methylene chloride and water. The aqueous layer was extracted with methylene chloride (3×150 mL). The combined organic layers were dried over magnesium sulfate, filtered, and concentrated to afford the crude product as a light brown oil which was purified on silica gel using a gradient of 100:0 to 60:40 hexanes:ethyl acetate over 35 minutes to afford the desired product as a clear oil (2.26 g, 27%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Fluoropyrazine, and friends who are interested can also refer to it.
Reference:
Patent; ASTRAZENECA AB; US2008/318943; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem