Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27825-21-4, name is Methyl 3-chloropyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H5ClN2O2
To a solution of the product from step 1 (100 mg, 0.58 mmoi) in toluene (2 mL) was added Pd(PPh3)4 (134 mg, 0.12 mmol) and 2ttributylstannyl)pyridine (213 mg, 0,58 mrnol) at room temperature and the resulting mixture heated to 100 C overnight. After cooling to RI, the mixture was filtered and 5 rnL of aq. KF solution was added to the filtrate. The resulting mixture was stirred for 30 mins and extracted with EtOAc (5 mL x3). The combined organic layerswere washed with brine, dried over Na2504, filtered and concentrated in vacuo, The residue was purified by chromatography (30% EtOAc in petroleum ether) to provide the title compound as a oil. LRMS nih (M-f-H) 216.1 found, 216,1 required.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 27825-21-4.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott D.; LIVERTON, Nigel; LUO, Yunfu; SKUDLAREK, Jason; (79 pag.)WO2016/95204; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem