In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 41110-29-6 as follows. COA of Formula: C7H8N2O2
To a stirred solution of the product of Step A (0.9 g, 5.9 mmol) in MeOH (20 mL) was added hydrazine hydrate (1.5g, 23.7 mmol) at RT. The mixture was stirred at 60 C overnight. The mixture was concentrated and the residue was dissolved into EA (30 mL) . The organic phase was washed with brine, dried over Na2SO4and concentrated under reduced pressure. The residue (460 mg, yield: 51.1%) was used into next step directly. MS: M/e 153 (M+1)+.
According to the analysis of related databases, 41110-29-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BEIGENE, LTD.; ZHANG, Guoliang; SUN, Hanzi; ZHOU, Changyou; (253 pag.)WO2020/20097; (2020); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem