In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55557-52-3, name is 3-Chloropyrazine-2-carbonitrile belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 3-Chloropyrazine-2-carbonitrile
2- cyano-3-(4-oxopiperidino)-pyrazine (Compound 56a)A mixture of 2-cyano-3-chloropyrazine (500 mg, 3.4 mmol), piperidin-4-one hydrochloridre monohydrate (1.33 g, 8.5 mmol) and TEA (1.8 ml, 10.3 mmol) in toluene (20 ml) was reacted at 80C for 8 h. After diluting with H20 and EtOAc, the organic phase was evaporated to dryness in vacuo. The crude was purified by automated flash chromatography (Horizon TM – Biotage) eluting with PE – EtOAc 80:20, affording a yellow solid. Yield: 69%.MS: [M+H]+ = 203.15
The synthetic route of 55557-52-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RECORDATI IRELAND LIMITED; LEONARDI, Amedeo; MOTTA, Gianni; RIVA, Carlo; GUARNERI, Luciano; GRAZIANI, Davide; MARINONI, Fabio; BETTINELLI, Ilaria; WO2011/29633; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem