Application of 486424-37-7, These common heterocyclic compound, 486424-37-7, name is 3-Amino-6-bromopyrazine-2-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution containing 1.63 g (7.5 mmol) of 2-amino-5-bromopyrazine carboxylic acid in 25 mL of DMF was added 3.54 g (9.36 mmol) of HATU. The reaction mixture was allowed to stir for 15 minutes before the addition of 1.68 g (9.36 mmol) of 3-amino-4- morpholinopyridine and 2.5 mL (22.5 mmol) of N-methylmorpholine. The reaction was stirred for 16 h then quenched with a 10 mL of a saturated NaHCO, solution and extracted with EtOAc three times. The combined organic extracts were washed with brine and dried over Na2S04. Evaporation of the solvent and column chromatography (Si02; 10% CH3OH /DCM) provided Intermediate A as a yellow solid. 1H NMR (CD3OD) d 9.51 (s, 1H), 8.76 (s, 1H), 8.39 (d, J=5.4Hz, 1H), 7.94 (d, J=8. lHz, 2H), 7.39-7.27 (m, 8H), 5.10 (s, 2H), 3.81 (t, J=7.5Hz, 4H), 2.96 (t, J=7.5Hz, 4H). [M+H]+ = 568.1.
Statistics shows that 3-Amino-6-bromopyrazine-2-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 486424-37-7.
Reference:
Patent; SILVERBACK THERAPEUTICS, INC.; SMITH, Sean Wesley; COBURN, Craig Alan; BAUM, Peter Robert; DUBOSE, Robert Finley; (335 pag.)WO2019/227059; (2019); A1;,
Pyrazine – Wikipedia,
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