Application of 160252-31-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 160252-31-3 name is 1-(5-Chloropyrazin-2-yl)ethanone, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of (4-(3-(cyclopropylmethoxy)phenoxy)-2,6-difluorophenyl)methanol (60 mg), 1-(5-chloropyrazin-2-yl)ethanone (33.7 mg), sodium hydride (60% in oil, 11.75 mg) and THF (1 ml) was stirred at room temperature for 10 min, and then stirred under microwave irradiation at 135C for 1 hr. To the mixture was added water at 0C, and the mixture was extracted with ethyl acetate. The organic layer was separated, washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The obtained residue was purified by HPLC (acetonitrile/water, addition of 0.1% TFA) to give the title compound (20 mg). 1H NMR (300 MHz, CDCl3) delta 0.31-0.42 (2H, m), 0.61-0.70 (2H, m), 1.22-1.30 (1H, m), 2.66 (3H, s), 3.79 (2H, d, J = 7.0 Hz), 5.47 (2H, s), 6.53-6.68 (4H, m), 6.76 (1H, ddd, J = 8.3, 2.4, 0.8 Hz), 7.27-7.34 (1H, m), 8.18-8.23 (1H, m), 8.81-8.88 (1H, m).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(5-Chloropyrazin-2-yl)ethanone, and friends who are interested can also refer to it.
Reference:
Patent; Takeda Pharmaceutical Company Limited; MIZOJIRI, Ryo; ASANO, Moriteru; TOMITA, Daisuke; BANNO, Hiroshi; TAWADA, Michiko; NII, Noriyuki; GIPSON, Krista E.; MAEZAKI, Hironobu; TSUCHIYA, Shuntaro; IMAI, Mayumi; AMANO, Yuichiro; (100 pag.)EP3279183; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem