Application of 55557-52-3, The chemical industry reduces the impact on the environment during synthesis 55557-52-3, name is 3-Chloropyrazine-2-carbonitrile, I believe this compound will play a more active role in future production and life.
[A] 1H-Pyrazolo [34-b] pyrazin-3-amine[0304][0305]To a stirred solution of 3-chloropyrazine-2-carbonitrile (5 g 35.8 mmol) in EtOH (100 mL) was added N2H4. H2O (85aq. 21 g 360 mmol) dropwise at 15 . After the addition the reaction mixture was allowed to warm up and stirred at 110 for 16 h. After cooling to room temperature the solvent was removed under reduced pressure and the residue solid was washed with EtOH (20 mL) to give a crude title compound (3 g 62yield) as a brown solid. MS 136.1 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloropyrazine-2-carbonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SAVIRA PHARMACEUTICALS GMBH; EUROPEAN MOLECULAR BIOLOGY LABORATORY; TAN, Xuefei; WANG, Lisha; CUMMING, John Graham; LIU, Yongfu; WU, Jun; LI, Dongbo; SHEN, Hong; SHI, Tianlai; (179 pag.)WO2017/133657; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem