55557-52-3, name is 3-Chloropyrazine-2-carbonitrile, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 55557-52-3
Step 1: Into a 2000 mL 4 necked round bottom flask purged and maintained with an inert atmosphere of nitrogen were placed a solution of 3-chloropyrazine-2-carbonitrile (100 g, 716 mmol) in ethanol (660 mL), ethyl 2-sulfanylacetate (112 g, 932 mmol) and sodium carbonate (99 g, 930 mmol). The resulting solution was stirred for 4.5 h at 100 C in an oil bath. The reaction mixture was cooled to room temperature and poured into 7.5 L of water. The solid was collected by filtration. The solid was dissolved in 1500 mL of ethyl ether and filtered. The filtrate was concentrated under reduced pressure. This resulted in ethyl 7-aminothieno[2,3-Z>]pyrazine-6- carboxylate as a solid.
The synthetic route of 55557-52-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIM, Jongwon; ALTMAN, Michael, D.; GIBEAU, Craig, R.; (84 pag.)WO2016/144849; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem