Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19847-12-2, name is Pyrazinecarbonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of Pyrazinecarbonitrile
Step 1 : To a mixture pyrazine-2-carbonitrile (2.0 g, 19.0 mmol) and 2-mercapto-propionic acid (2.1 g, 19.04 mmol) was added pyridine (3.0 mL, 38.1 mmol) and the mixture was heated to 100C for 2 h. The mixture was cooled to rt and EtOH (100 mL) was added and the RM was stirred at rt for 30 min. The formed precipitate was isolated though filtration and was washed with hex and was dried under reduced pressure to yield the desired compound (3.0 g, 15.5 mmol, 81 %). LC-MS (method 3): mlz [M+H]+ = 194.0 (MW calc. = 193.23); R, = 2.42 min.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; GRUeNENTHAL GMBH; VOSS, Felix; RITTER, Stefanie; NORDHOFF, Sonja; WACHTEN, Sebastian; OBERBOeRSCH, Stefan; KLESS, Achim; WO2015/22073; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem