These common heterocyclic compound, 912773-24-1, name is 6-Bromoimidazo[1,2-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 912773-24-1
Synthesis of 6-bromo-3-iodoimidazo[ 1 ,2-a]pyrazineA degassed solution of 6-bromoimidazo[l,2-a]pyrazine (500 mg, 2.52 mmol) and NIS (852 mg, 3.79 mmol) in DMF (10 mL) was heated to 60 C for 10 hours. The reaction mixture was cooled to RT and extract with DCM. The organics were washed with Na2S203 (aq), brine and dried over Na2S04. After concentrated, the crude product was purified by column (PE : EtOAc = 5 : 1) to obtain 6-bromo-3-iodoimidazo[l,2-a]pyrazine (530 mg, yield: 65%). 1H-NMR (CDC13, 400 MHz) delta 8.75 (s, 1H), 8.18 (s, 1H), 7.82 (s, 1H). MS (M+H)+: 324 / 326.
The synthetic route of 6-Bromoimidazo[1,2-a]pyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MCCOMAS, Casey Cameron; LIVERTON, Nigel J.; HABERMANN, Joerg; KOCH, Uwe; NARJES, Frank; LI, Peng; PENG, Xuanjia; SOLL, Richard; WU, Hao; PALANI, Anandan; DAI, Xing; LIU, Hong; HE, Shuwen; DANG, Qung; WO2013/34048; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem