Synthetic Route of 16298-03-6,Some common heterocyclic compound, 16298-03-6, name is Methyl 2-aminopyrazine-3-carboxylate, molecular formula is C6H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of methyl 3-aminopyrazine-2-carboxylate (6.30 g, 41.14 mmol, 1 eq.) andiV- o bromosuccinimide (7.322 g, 41.14 mmol, 1 eq.) in 100 mL acetonitrile was refiuxed for 2 h until there was no starting material left according to LC/MS. The solvent was removed in vacuo. To the residue was added isopropanol. After filtration, the crude product was collected as a solid. Additional product could be collected from the mother solution. Thus, 12.136 g of crude product was obtained (127 %). The crude product was used directly in 5 the next step without further purification.1H NMR (400 MHz, DMSO-cfc) delta (ppm) 3.85 (s, 3H)5 7.55 (br s, 2H), 8.42 (s, IH).
The synthetic route of 16298-03-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; WO2007/61360; (2007); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem