Electric Literature of 486460-20-2, A common heterocyclic compound, 486460-20-2, name is 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine, molecular formula is C6H3F3N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 5.0 g (26.6 mmol) of 3- (trifluoromethyl) -1,2,4-triazolo [4,3-a] pyrazine 3.0 g and a mass fraction of5% by weight of palladium on charcoal was charged into a 100 ml three-necked flask containing 50 ml of absolute ethanol and hydrogen gas was bubbled at 30 C under magnetic stirring,Atmospheric hydrogenation 20H, after the reaction is filtered, the filtrate by activated carbon decolorization, the column chromatography, yellow-brown liquid 3.5G, the yield 68.5%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Nankai University; Wang, Baolei; Li, Zhengming; Zhang, Yan; (13 pag.)CN106749262; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem