Synthetic Route of 21948-70-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21948-70-9, name is 2-Methylthiopyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Example 41Preparation of Compound 215Step A – Synthesis of 2-BenzylpyrazineTo a solution of 2-methylsulfanyl-pyrazine (1.26 g, 10 mmol) in 15 mL THF was added benzylzinc bromide (0.5M in THF, 40 mL, 20 mmol) followed by Pd(Ph3P)4 (1.16 g, 1 mmol). The resulting reaction was heated to 60 C and allowed to stir at this temperature for 2 hours, after which time the reaction mixture was cooled to room temperature, diluted with ethyl acetate and washed with saturated sodium bicarbonate solution. The organic fraction was dried (sodium sulfate), filtered, and concentrated in vacuo to provide a crude residue which was purified using flash column chromatography (15% ethyl acetate in hexane) to provide 2- benzylpyrazine (0.76 g, 45% yield).
The synthetic route of 2-Methylthiopyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SCHERING CORPORATION; WO2008/130581; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem