Application of 117719-17-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 117719-17-2, name is 5-Bromo-3-morpholinopyrazin-2-amine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Preparation of Intermediate I-28. Intermediate I-02 (1.2 g, 4.7 mmol) and ethyl 2-chloroacetoacetate (2.3 g, 14.2 mmol) were suspended in EtOH (12 mL). The mixture was heated under microwave irradiation for 1 h at 150 C. After cooling down to room temperature, petroleum ether was added and the solid formed was filtered off. The filtrate was evaporated under reduced pressure and the residue was purified by flash chromatography on silica gel (c-Hex/EtAOAc 8:2) to obtain a solid that was washed with petroleum ether to give the desired product I-28 (231 mg, Y: 33%).
The synthetic route of 5-Bromo-3-morpholinopyrazin-2-amine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Centro Nacional De Investigaciones Oncologicas (CNIO); US2012/83492; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem