In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 59489-71-3 as follows. Recommanded Product: 59489-71-3
In a sealed tube, sodium methoxide (25 wt. %, 10 mL) was added to a suspension of 5-bromopyrazin-2-amine (1.12 g, 6.44 mmol) in MeOH (10 mL). The reaction was stirred at 100C for 40 h. At 15 h reaction time, reaction is about 40 % complete by LCMS. At 40 h reaction time, reaction is about 90% complete. After concentration the residue was taken up in EtOAc and extracted with brine, dried over sodium sulfate, concentrated and purified by flash chromatography on a 120 g silica gel cartridge with 30 to 50% EtOAc in hexane, 45 min, at 35 mL/min. Pure fractions were pooled, concentrated and dried under high vac to give 5-methoxypyrazin-2-amine (455 mg, 57 %).1H NMR (400 MHz, CDCl3) d ppm 7.75 (1 H, d, J=1.26 Hz), 7.55 (1 H, d, J=1.51 Hz), 4.12 (2 H, br. s.), 3.87 (3 H, s). LCMS (method K) tR, 0.55min., MH+ = 126.1.
According to the analysis of related databases, 59489-71-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Iwuagwu, Christiana; King, Dalton; McDonald, Ivar M.; Cook, James; Zusi, F. Christopher; Hill, Matthew D.; Mate, Robert A.; Fang, Haiquan; Knox, Ronald; Gallagher, Lizbeth; Post-Munson Amy Easton, Debra; Miller, Regina; Benitex, Yulia; Siuciak, Judy; Lodge, Nicholas; Zaczek, Robert; Morgan, Daniel; Bristow, Linda; Macor, John E.; Olson, Richard E.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 5; (2017); p. 1261 – 1266;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem