Synthetic Route of 87597-21-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 87597-21-5 as follows.
Preparation of Intermediate I-36. Intermediate I-07 (0.50 g, 1.40 mmol) was suspended in DCE (8 mL) and piperidine (0.18 mL, 1.7 mmol) was added dropwise. The reaction mixture was heated at 60 C. for 16 h. Additional piperidine (0.05 mL) was added and heating continued for 2 h. The suspension at RT was filtered affording a solid (impurities) and the filtrate that was concentrated. The resulting residue was triturated with Et2O to render another solid (impurities) and the filtrate that was concentrated to afford the required intermediate I-36 as light orange solid (400 mg, Y: 80%).
According to the analysis of related databases, 87597-21-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Centro Nacional De Investigaciones Oncologicas (CNIO); US2012/83492; (2012); A1;,
Pyrazine – Wikipedia,
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