Synthetic Route of 17231-51-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17231-51-5, name is 3-Amino-6-bromopyrazine-2-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.
Step 1: 3-Amino-6-bromo-N?-hydroxypyrazine-2-carboximidam ide To a 20m1 flask was added 3-amino-6-bromopyrazine-2-carbonitrile (600 mg, 3.01 mmol) inMeOH (12 ml) and cooled to 000. To the reaction mixture was added hydroxylaminehydrochloride (210 mg, 3.01 mmol) and triethylamine (0.420 ml, 3.01 mmol) and the mixturewas allowed to warm to room temperature as a precipitate formed. The precipitate was filtered off and washed with MeOH. The filtrate was concentrated under reduced pressure and the resulting solid triturated in MeOH to give a second crop of product. The solid was triturated in MeOH again and sonicated for l5mins until a suspension formed. The solid wasfiltered off and dried in a vacuum oven at 40C for 3 hours to afford the title compound;1H NMR (400MHz, DMSO-d6), O 10.38 (1H, 5), 8.15 (1H, 5), 7.64 (2H, brs), 5.88 (2H, 5).
The chemical industry reduces the impact on the environment during synthesis 3-Amino-6-bromopyrazine-2-carbonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; NOVARTIS AG; BELLENIE, Benjamin Richard; BLOOMFIELD, Graham Charles; BRUCE, Ian; CULSHAW, Andrew James; HALL, Edward Charles; HOLLINGWORTH, Gregory; NEEF, James; SPENDIFF, Matthew; WATSON, Simon James; (395 pag.)WO2015/162459; (2015); A1;,
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