Application of 108-50-9, These common heterocyclic compound, 108-50-9, name is 2,6-Dimethylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE II Preparation Of 1,2-Bis(6-methyl-2pyrazyl)ethane STR10 The reaction of 5.40 grams (0.05 mole) of 2,6-dimethylpyrazine with 0.05 mole of lithium diisopropylamide and 6.35 grams (0.025 mole) of iodine was carried out as described in Method A of Example I. A crude product was obtained as previously described and the dimeric pyrazine was purified by elution chromatography to yield 1.9 grams (36%) of pure material. Recrystallization from hexane gave plates, m.p. 99-101 C.
Statistics shows that 2,6-Dimethylpyrazine is playing an increasingly important role. we look forward to future research findings about 108-50-9.
Reference:
Patent; Philip Morris Incorporated; US4620004; (1986); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem