Electric Literature of 19847-12-2,Some common heterocyclic compound, 19847-12-2, name is Pyrazinecarbonitrile, molecular formula is C5H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 2-Cyanopyridine (0.420 ml; 4 mmol) was dissolved in absolute methanol (20 ml) and to it was added sodium methoxide solution in methanol (1.0 ml) (previously prepared). The reaction contents were stirred at room temperature for 2 h 1,4-diaminobutane (0.18 ml, 2 mmol) was added to the reaction mixture. Reaction contents were heated under reflux for 12 h. Solvent was removed under reduced pressure. Crude product so obtained was washed with diethyl ether and then with ethyl acetate to give thick mass. Solvent traces from this thick mass was removed by applying high vacuum for 15 min to give semisolid product i.e. N-(2-pyridineimidoylamino-butyl)-pyridine-2-carboxamidine (5a). Yield 480 mg (81%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazinecarbonitrile, its application will become more common.
Reference:
Article; Arya, Surbhi; Kumar, Nikhil; Roy, Partha; Sondhi; European Journal of Medicinal Chemistry; vol. 59; (2013); p. 7 – 14;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem