Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 173253-42-4, name is 2-Amino-5-bromo-6-chloropyrazine, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Amino-5-bromo-6-chloropyrazine
In a pressure tube were mixed 2-amino-5-bromo-6-chloropyrazine (2.00 g, 9.60 mmol), 3-fluor-ophenylboronic acid (1.48 g, 10.55 mmol), sodium carbonate (2.03 g, 19.19 mmol) in a 4:1 mixture of 1 ,4-dioxane : water (25 mL). The reaction mixture was sparged with argon and Pd(PPh3)4 (0.22 g, 0.20 mmol) was then added. The mixture was sparged with argon shortly and the vessel was sealed and the reaction mixture was heated at 10000 for 20h. After that time the reaction mixture was cooled down to r.t. filtered through Celite pad diluted with AcOEt, or-ganic layer was washed with NaHCO3, brine and dried over Na2SO4. Then the mixture was concentrated under reduced pressure. The obtained residue was purified by flash chromatography on silica eluting with hexane : EtOAc (1:0 – 1:1) to lead to the title product as a light yellow solid(1 .82 g, 85%). ESI-MS: 224.00 [M+H].
The synthetic route of 173253-42-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SELVITA S.A.; BOBOWSKA (NEE WITKOWSKA), Aneta; GALEZOWSKI, Michal; NOWAK, Mateusz; COMMANDEUR, Claude; SZEREMETA-SPISAK, Joanna; NOWOGRODZKI, Marcin; OBARA, Alicja; DZIELAK, Anna; LOZINSKA, Iwona; DUDEK (NEE SEDLAK), Marcelina; JANIGA, Anita; REUS, Jacek; WRONOWSKI, Marek; ZASTAWNA, Magdalena; RADZIMIERSKI, Adam; SWIRSKI, Mateusz; ZACHMANN, Julian; FABRITIUS, Charles-Henry; PORTER, Rod; FOGT, Joanna; (276 pag.)WO2019/2606; (2019); A1;,
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