Reference of 6705-33-5,Some common heterocyclic compound, 6705-33-5, name is Pyrazin-2-ylmethanol, molecular formula is C5H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Dissolve 2-pyrazinylmethanol (2.0 g, 18.1 mmol) in DCM (200 mL) and cool to 0C while stirring under nitrogen. Add thionyl chloride (4.63 mL, 63.6 mmol) drop wiseover 10 mm, and allow to warm to 25 C. Stir at room temperature for 16 h. Concentrate the mixture and then dilute with DCM. Wash the crude solution with saturated NaHCO3, dry over Mg504, filter, and concentrate. Dissolve the crude residue in DCM and purify by silica gel flash chromatography (hexane/EtOAc, 95:5 to 100% EtOAc gradient) to give the title compound as a pale yellow oil. 1H NMR (400 MHz, CDC13) oe 4.67 (s = 2H),8.50-8.55 (m, 2H), 8.73 (s, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazin-2-ylmethanol, its application will become more common.
Reference:
Patent; ELI LILLY AND COMPANY; CHEDID, Marcio; EISSA, Hisham Omer; ENGLER, Thomas Albert; FURNESS, Kelly Wayne; RANK, Kenneth B.; WOODS, Timothy Andrew; WROBLESKI, Aaron D.; WO2015/69512; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem