Application of 14508-49-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14508-49-7, name is 2-Chloropyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 2-chloropyrazine 1 (0.8 mL, 8.96 mmol) in dry 1,2-dichloroethane (15 mL) was added 3-chloroperbenzoic acid (mCPBA, 2.47 g, 14.34 mmol, 1.6 equiv). The reaction mixture was stirred at 65 C for 30 h and then cooled to room temperature. The mixture was washed with a 1 M NaOH solution, a saturated Na2S2O3 solution, water and then dried over Na2SO4. The filtrate was concentrated under reduced pressure, to give the title compound as white solid (0.95 g, 81%). 1H NMR (300 MHz, CDCl3) delta 8.24 (d, J = 4.1 Hz, 1H, H-6), 8.18-8.10 (m, 1H, H-3), 8.01 (dd, J = 4.1, 1.5 Hz, 1H, H-5). 13C NMR (75 MHz, CDCl3) delta 151.9 (C-2), 146.1 (C-6), 133.6 (C-3), 133.3 (C-5).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloropyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Plebanek, Elzbieta; Lescrinier, Eveline; Andrei, Graciela; Snoeck, Robert; Herdewijn, Piet; De Jonghe, Steven; European Journal of Medicinal Chemistry; vol. 144; (2018); p. 93 – 103;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem