In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-aminopyrazine-3-carboxylate, other downstream synthetic routes, hurry up and to see.
Application of 16298-03-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16298-03-6, name is Methyl 2-aminopyrazine-3-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Preparation of 3-aminopyrazine-2-carbaldehyde EPO Mthetathyl-3-aminopyrazine-2-carboxylate (11g) was dissolved in THF and cooled to – 780C. Diisobutylaluminum hydride (1 M in hexanes, 25OmL) was added, and the reaction stirred at -78C for 4 hours. The reaction was then warmed to 00C for one hour before being quenched slowly by addition of 1 M hydrochloric acid. Ethyl acetate was added and the layers separated. The organic layer was dried over magnesium sulfate, filtered and concentrated. The residue was triturated in hexanes to afford title compound (3.Og, 34%).1H NMR (400 MHz, DMSO-D6) delta ppm 7.73 (br, 2H), 8.07 (d, J=2.25 Hz, 1 H), 8.36 (d, J=2.11 Hz, 1 H), 9.95 (s, 1 H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-aminopyrazine-3-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/63167; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem