Reference of 5521-55-1,Some common heterocyclic compound, 5521-55-1, name is 5-Methylpyrazine-2-carboxylic acid, molecular formula is C6H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To the starting material 5-methylpyrazine-2-carboxylic acid (2.0 g 0.145 mmol), methanol(20.0 mL), sulfuric acid (0.2 mL) and molecular sieves 4 A (catalytic) was added and thereaction mixture was heated to reflux for 8 h. TLC revealed complete consumption ofstarting material after 8 h. The solvent was evaporated, EtOAC (25 mL) was added andwater (10 mL) was added and the layers were separated. The aqueous layer wasextracted twice with EtOAC (25 mL) and organic layers were pooled together, washedwith brine solution (25 mL). The organic layer was dried over sodium sulfate andevaporated under reduced pressure to dryness. The compound was purified and washedusing diethyl ether (10 mL). Yield: 81%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Methylpyrazine-2-carboxylic acid, its application will become more common.
Reference:
Article; Balasubramaniam, Sivaraman; Vijayan, Sajith; Goldman, Liam V.; May, Xavier A.; Dodson, Kyra; Adhikari, Sweta; Rivas, Fatima; Watkins, Davita L.; Stoddard, Shana V.; Beilstein Journal of Organic Chemistry; vol. 16; (2020); p. 628 – 637;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem